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phenobarbital will decrease the extent or influence of olanzapine/samidorphan by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Solid CYP3A4 inducers minimize amounts of olanzapine and samidorphan by~fifty% and ~seventy five% respectively.phenobarbital will lessen the extent or influence of bosentan by a